Fresh analysis reveals that people who stop using blockbuster slimming jabs like Wegovy and Mounjaro can put back on shed pounds far faster than those who end conventional lifestyle programs.
Research printed in a major health publication points out that while overweight individuals can lose a large proportion of their total mass while on the medication, the weight is regained at an average rate of 0.8 kg per month once they quit.
"Individuals purchasing such drugs should be cognizant of the risk of fast rebound weight gain when the medication concludes," warns expert Dr. Susan Jebb.
That rate of recovery suggests a reversion to original weight within about one and a half years.
Comparing Therapies
The research, which reviewed dozens of studies involving thousands of patients, contrasted the outcomes of the injectable medications with conventional dieting.
Researchers emphasize that individuals who shed pounds through diet and exercise typically have a more gradual weight regain—around 0.1 kg a month—post-intervention.
Explaining the Quick Regain
Nutrition scientists suggest the way of the injections accounts for the amplified regain.
GLP-1 drugs copy a natural hormone called glucagon-like peptide-1, which moderates feelings of fullness.
"Sustained high doses of the hormone levels several times higher than the body's typical production might result in the body to generate a reduced amount of its endogenous GLP-1, and may also reduce responsiveness to its effects," noted Dr. Adam Collins, a nutrition researcher.
"Discontinuation of this hormone supplement means appetite is uncontrolled, making overeating a significant risk."
An Ongoing Condition?
The NHS suggest the jabs for individuals with obesity-related medical conditions, accompanied by recommended diet and exercise modifications.
Professionals say that, given the likelihood of relapse, the treatment should be considered life-long.
This perspective is echoed by pharmaceutical companies, who say that the results "underscore the chronic nature of obesity," akin to managing conditions like diabetes.
Patient Testimonies
People who have discontinued the jabs report a powerful resurgence of hunger.
"I experienced a trigger that goes on and you're instantly ravenous," said an individual.
The struggle is exacerbated if individuals have not adopted lasting lifestyle or habit modifications during therapy.
Growing Adoption
Figures indicate that millions of adults in the UK have tried weight-loss jabs in the past year, with interest being substantial.
- Adoption is higher among females compared to men.
- The middle-aged demographic shows the greatest level of interest.
- Many access the medications through private healthcare rather than public health services.
Finally, experts emphasize that while the jabs are potent tools for weight loss, they are not a standalone solution and maintained weight loss hinges on ongoing lifestyle support.
